Pathophysiology of Citrobacter diversus neonatal meningitis: comparative studies in an infant mouse model

Pathophysiology of Citrobacter diversus neonatal meningitis: comparative studies in an infant mouse model.

Citrobacter diversus is a cause of devastating neonatal meningitis, with illness characterized by formation of multiple brain abscesses. We developed an infant mouse intracranial inoculation model to evaluate the pathophysiology of C. diversus neonatal infections. Eighteen of 26 strains inoculated intracranially at a dose of ca. 3.3 x 10(3) CFU caused greater than 50% mortality in 2-day-old mic...

Brain abscesses in neonatal Citrobacter diversus meningitis SWISS SOCIETY OF NEONATOLOGY

Neonatal citrobacter meningitis.

The genus Citrobacter has long been recognized as a saprophyte in the alimentary tract of man (Wilson and Miles, 1964), but its role as a pathogen has been questioned. It is frequently cultured together with other organisms in mixed growths from wounds, urines, and sputa from adults, when it is usually an unimportant saprophyte. We present evidence showing that this organism can be pathogenic, ...

Neonatal citrobacter meningitis: neurosonographic observations.

Meningitis caused by gram-negative enteric bacteria usually is limited in children to the neonatal period. Among neonates, the disease is severe, with a mortality of up to 80%. The most common etiologic agent in this type of meningitis is Escherichia coli. Meningitis due to Citrobacter diversus has occurred in sporadic small outbreaks throughout the United States. This devastating disease frequ...

Neonatal meningitis caused by Citrobacter koseri.

Three cases of neonatal meningitis, two of which were fatal, occurred in a premature baby unit during a period of one week. A fourth case occurred in the same unit six months later. Citrobacter koseri was isolated from the cerebrospinal fluid of all four cases. Detailed biochemical and serological examination of the organisms showed that two distinct bioserotypes were involved.